In the Advanced section, scroll down to the 'General' portion, and in the 'At startup, open all files in' textbox, input the following: C: Program Files QIMacros xlstart.Open Excel and select File >Options >Advanced.This is because your Microsoft security settings has removed the Alternate Startup pathway in Excel, once closed: Download, Enable and Click on button in this file: Manual way to restore QI Macros Addin: